About 30 results found for searched term "Y 11" (0.009 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1694 | CYC116 | Aurora Kinase |
| CYC116 is a potent, small molecule inhibitor of Aurora A, B and C with IC50 value of 44, 19 and 65 nM respectively. | ||
| M1700 | Momelotinib (CYT387) | JAK |
| LM-1149; Momelotinib; CYT 11387 | ||
| Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. | ||
| M1716 | Gemcitabine Hydrochloride | DNA/RNA Synthesis |
| Gemzar, LY-188011 | ||
| Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. | ||
| M1864 | SYN115 | Adenosine Receptor |
| Tozadenant | ||
| SYN115 is a novel, selective adenosine A(2A) receptor antagonist. | ||
| M1910 | Nepicastat hydrochloride | Dopamine Receptor |
| SYN117 | ||
| Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. | ||
| M2040 | BAY 11-7082 | IκB/IKK |
| BAY 11-7821 | ||
| BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). | ||
| M2130 | LY-411575 | Gamma-secretase/Beta-secretase |
| LSN-411575 | ||
| LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. | ||
| M2172 | LY2811376 | Gamma-secretase/Beta-secretase |
| LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM. | ||
| M2435 | Bay 11-7085 | IκB/IKK |
| Bay 11-7083 | ||
| BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. | ||
| M2800 | KY02111 | Wnt/beta-catenin |
| KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M3267 | Nepicastat | Others |
| SYN117, RS-25560-197 | ||
| Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ±0.8 and 9.0 ±0.8 nM for bovine and human, respectively. | ||
| M3633 | Refametinib | MEK |
| BAY 86-9766, RDEA119 | ||
| Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3886 | WAY-262611 | Wnt/beta-catenin |
| WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM. | ||
| M1629 | Ramucirumab | VEGFR/PDGFR |
| LY3009806; IMC-1121B | ||
| Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). | ||
| M4319 | 23S-hydroxyl-11,15-dioxo-ganoderic-acid-DM | Others |
| 23S-hydroxyl-11,15-dioxo-ganoderic-acid-DM | ||
| M4852 | LY303511 | mTOR |
| LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC. | ||
| M11228 | BAY1125976 | Akt |
| BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively. | ||
| M5134 | WAY-181187 | 5-HT Receptor |
| Way-181187 (SAX-187) is an effective selective 5-HT6 receptor agonist with Ki of 2.2 nM and EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signaling pathways, such as cAMP, Fyn and ERK1/2 kinases, as specific agonists. | ||
| M5285 | Ilaprazole | Proton Pump |
| IY-81149 | ||
| Ilaprazole, a substituted benzimidazole, is a new candidate drug that is an H+ /K+ ATPase inhibitor designed for the treatment of gastric ulcers. | ||
| M5533 | Corticosterone | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | ||
| Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. | ||
| M5534 | Cortisone | GCR |
| 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E | ||
| Cortisone is a 21-carbon steroid hormone. Cortisone is one of the main hormones released by the adrenal gland in response to stress. | ||
| M5656 | Fluoxetine hydrochloride | 5-HT Receptor |
| LY-110140 | ||
| Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. | ||
| M5680 | Gemcitabine | DNA/RNA Synthesis |
| NSC 613327; LY188011 | ||
| Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. | ||
| M5916 | Radotinib | Src-bcr-Abl |
| IY-5511 | ||
| Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia. | ||
| M5952 | Saxagliptin hydrate | Dipeptidyl Peptidase |
| BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate | ||
| Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | ||
| M6289 | Erythromycin cyclocarbonate | Antibiotic |
| Erythromycin cyclic carbonate; Erythromycin A 11,12-carbonate | ||
| Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. | ||
| M6389 | 1-Aminobenzotriazole (ABT) | Cytochrome P450 (e.g. CYP17) |
| ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 | ||
| 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. | ||
| M7482 | WAY 181187 oxalate | Others |
| WAY 181187 oxalate is a high affinity and selective 5-HT 6 agonist. | ||
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